Development of bisphenol A (BPA)-sensing indicator Arabidopsis thaliana which synthesizes anthocyanin in response to BPA in leaves.
Identifieur interne : 000A32 ( Main/Exploration ); précédent : 000A31; suivant : 000A33Development of bisphenol A (BPA)-sensing indicator Arabidopsis thaliana which synthesizes anthocyanin in response to BPA in leaves.
Auteurs : Donggwan Kim [Corée du Sud] ; Ramin Bahmani [Corée du Sud] ; Jae-Heung Ko [Corée du Sud] ; Seongbin Hwang [Corée du Sud]Source :
- Ecotoxicology and environmental safety [ 1090-2414 ] ; 2019.
Descripteurs français
- KwdFr :
- Anthocyanes (biosynthèse), Anthocyanes (génétique), Arabidopsis (effets des médicaments et des substances chimiques), Arabidopsis (génétique), Arabidopsis (métabolisme), Colorimétrie (méthodes), Composés benzhydryliques (analyse), Composés benzhydryliques (toxicité), Facteurs de transcription (génétique), Feuilles de plante (effets des médicaments et des substances chimiques), Feuilles de plante (génétique), Feuilles de plante (métabolisme), Perturbateurs endocriniens (analyse), Perturbateurs endocriniens (toxicité), Phénols (analyse), Phénols (toxicité), Régulation de l'expression des gènes végétaux (effets des médicaments et des substances chimiques), Techniques de biocapteur (méthodes), Végétaux génétiquement modifiés (effets des médicaments et des substances chimiques), Végétaux génétiquement modifiés (génétique), Végétaux génétiquement modifiés (métabolisme).
- MESH :
- analyse : Composés benzhydryliques, Perturbateurs endocriniens, Phénols.
- biosynthèse : Anthocyanes.
- effets des médicaments et des substances chimiques : Arabidopsis, Feuilles de plante, Régulation de l'expression des gènes végétaux, Végétaux génétiquement modifiés.
- génétique : Anthocyanes, Arabidopsis, Facteurs de transcription, Feuilles de plante, Végétaux génétiquement modifiés.
- métabolisme : Arabidopsis, Feuilles de plante, Végétaux génétiquement modifiés.
- méthodes : Colorimétrie, Techniques de biocapteur.
- toxicité : Composés benzhydryliques, Perturbateurs endocriniens, Phénols.
English descriptors
- KwdEn :
- Anthocyanins (biosynthesis), Anthocyanins (genetics), Arabidopsis (drug effects), Arabidopsis (genetics), Arabidopsis (metabolism), Benzhydryl Compounds (analysis), Benzhydryl Compounds (toxicity), Biosensing Techniques (methods), Colorimetry (methods), Endocrine Disruptors (analysis), Endocrine Disruptors (toxicity), Gene Expression Regulation, Plant (drug effects), Phenols (analysis), Phenols (toxicity), Plant Leaves (drug effects), Plant Leaves (genetics), Plant Leaves (metabolism), Plants, Genetically Modified (drug effects), Plants, Genetically Modified (genetics), Plants, Genetically Modified (metabolism), Transcription Factors (genetics).
- MESH :
- chemical , analysis : Benzhydryl Compounds, Endocrine Disruptors, Phenols.
- chemical , biosynthesis : Anthocyanins.
- chemical , genetics : Anthocyanins, Transcription Factors.
- drug effects : Arabidopsis, Gene Expression Regulation, Plant, Plant Leaves, Plants, Genetically Modified.
- genetics : Arabidopsis, Plant Leaves, Plants, Genetically Modified.
- metabolism : Arabidopsis, Plant Leaves, Plants, Genetically Modified.
- methods : Biosensing Techniques, Colorimetry.
- chemical , toxicity : Benzhydryl Compounds, Endocrine Disruptors, Phenols.
Abstract
Bisphenol A (BPA) is an estrogenic endocrine disruptor which disturbs a normal animal development. We generated an indicator plant that senses and provides a clear visual indicator of an estrogen-like compound BPA in the environment. We developed transgenic Arabidopsis lines expressing a construct designed to synthesize anthocyanin (thus showing a red color) in response to BPA. We transformed Arabidopsis with a recombinant vector containing the chimeric estrogen receptor (XVE region), LAP and coding region of PtrMYB119 (transcription factor involved in anthocyanin biosynthesis in poplar and Arabidopsis). Upon binding of the estrogen compound to the ligand-binding domain of E (estrogen receptor) in XVE, the XV domain binds to LAP promoter and triggering the transcription of PtrMYB119 with a subsequent enhancement of anthocyanin biosynthetic gene expression, resulting in anthocyanin synthesis. The leaves of the transgenic Arabidopsis line XVE-PtrMYB119 turned red in the presence of 10 ppm BPA. The transcript level of PtrMYB119 peaked at day 3 of BPA exposure, then decreased to its minimal level at day 5. Similar expression patterns to that of PtrMYB119 were detected for genes encoding the anthocyanin biosynthetic enzymes chalcone synthase, chalcone flavanone isomerase, flavanone 3-hydroxylase, dihydroflavonol 4-reductase, anthocyanidin synthase, and UFGT (UGT78D2). The leaves of transgenic plants did not turn red in response to BPA at concentrations below 10 ppm, but PtrMYB119 expression was induced by BPA at concentrations as low as 1 ppt BPA. Since this transgenic plant turns red in the presence of BPA without any experimental procedures, this line can be easily used by non-scientists.
DOI: 10.1016/j.ecoenv.2018.12.029
PubMed: 30579163
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Compounds (toxicity)</term><term>Biosensing Techniques (methods)</term><term>Colorimetry (methods)</term><term>Endocrine Disruptors (analysis)</term><term>Endocrine Disruptors (toxicity)</term><term>Gene Expression Regulation, Plant (drug effects)</term><term>Phenols (analysis)</term><term>Phenols (toxicity)</term><term>Plant Leaves (drug effects)</term><term>Plant Leaves (genetics)</term><term>Plant Leaves (metabolism)</term><term>Plants, Genetically Modified (drug effects)</term><term>Plants, Genetically Modified (genetics)</term><term>Plants, Genetically Modified (metabolism)</term><term>Transcription Factors (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anthocyanes (biosynthèse)</term><term>Anthocyanes (génétique)</term><term>Arabidopsis (effets des médicaments et des substances chimiques)</term><term>Arabidopsis (génétique)</term><term>Arabidopsis (métabolisme)</term><term>Colorimétrie (méthodes)</term><term>Composés benzhydryliques 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xml:lang="fr"><term>Colorimétrie</term><term>Techniques de biocapteur</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Benzhydryl Compounds</term><term>Endocrine Disruptors</term><term>Phenols</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Composés benzhydryliques</term><term>Perturbateurs endocriniens</term><term>Phénols</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bisphenol A (BPA) is an estrogenic endocrine disruptor which disturbs a normal animal development. We generated an indicator plant that senses and provides a clear visual indicator of an estrogen-like compound BPA in the environment. We developed transgenic Arabidopsis lines expressing a construct designed to synthesize anthocyanin (thus showing a red color) in response to BPA. We transformed Arabidopsis with a recombinant vector containing the chimeric estrogen receptor (XVE region), LAP and coding region of PtrMYB119 (transcription factor involved in anthocyanin biosynthesis in poplar and Arabidopsis). Upon binding of the estrogen compound to the ligand-binding domain of E (estrogen receptor) in XVE, the XV domain binds to LAP promoter and triggering the transcription of PtrMYB119 with a subsequent enhancement of anthocyanin biosynthetic gene expression, resulting in anthocyanin synthesis. The leaves of the transgenic Arabidopsis line XVE-PtrMYB119 turned red in the presence of 10 ppm BPA. The transcript level of PtrMYB119 peaked at day 3 of BPA exposure, then decreased to its minimal level at day 5. Similar expression patterns to that of PtrMYB119 were detected for genes encoding the anthocyanin biosynthetic enzymes chalcone synthase, chalcone flavanone isomerase, flavanone 3-hydroxylase, dihydroflavonol 4-reductase, anthocyanidin synthase, and UFGT (UGT78D2). The leaves of transgenic plants did not turn red in response to BPA at concentrations below 10 ppm, but PtrMYB119 expression was induced by BPA at concentrations as low as 1 ppt BPA. Since this transgenic plant turns red in the presence of BPA without any experimental procedures, this line can be easily used by non-scientists.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">30579163</PMID><DateCompleted><Year>2019</Year><Month>02</Month><Day>13</Day></DateCompleted><DateRevised><Year>2019</Year><Month>02</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1090-2414</ISSN><JournalIssue CitedMedium="Internet"><Volume>170</Volume><PubDate><Year>2019</Year><Month>Apr</Month><Day>15</Day></PubDate></JournalIssue><Title>Ecotoxicology and environmental safety</Title><ISOAbbreviation>Ecotoxicol Environ Saf</ISOAbbreviation></Journal><ArticleTitle>Development of bisphenol A (BPA)-sensing indicator Arabidopsis thaliana which synthesizes anthocyanin in response to BPA in leaves.</ArticleTitle><Pagination><MedlinePgn>627-634</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0147-6513(18)31320-4</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ecoenv.2018.12.029</ELocationID><Abstract><AbstractText>Bisphenol A (BPA) is an estrogenic endocrine disruptor which disturbs a normal animal development. We generated an indicator plant that senses and provides a clear visual indicator of an estrogen-like compound BPA in the environment. We developed transgenic Arabidopsis lines expressing a construct designed to synthesize anthocyanin (thus showing a red color) in response to BPA. We transformed Arabidopsis with a recombinant vector containing the chimeric estrogen receptor (XVE region), LAP and coding region of PtrMYB119 (transcription factor involved in anthocyanin biosynthesis in poplar and Arabidopsis). Upon binding of the estrogen compound to the ligand-binding domain of E (estrogen receptor) in XVE, the XV domain binds to LAP promoter and triggering the transcription of PtrMYB119 with a subsequent enhancement of anthocyanin biosynthetic gene expression, resulting in anthocyanin synthesis. The leaves of the transgenic Arabidopsis line XVE-PtrMYB119 turned red in the presence of 10 ppm BPA. The transcript level of PtrMYB119 peaked at day 3 of BPA exposure, then decreased to its minimal level at day 5. Similar expression patterns to that of PtrMYB119 were detected for genes encoding the anthocyanin biosynthetic enzymes chalcone synthase, chalcone flavanone isomerase, flavanone 3-hydroxylase, dihydroflavonol 4-reductase, anthocyanidin synthase, and UFGT (UGT78D2). The leaves of transgenic plants did not turn red in response to BPA at concentrations below 10 ppm, but PtrMYB119 expression was induced by BPA at concentrations as low as 1 ppt BPA. Since this transgenic plant turns red in the presence of BPA without any experimental procedures, this line can be easily used by non-scientists.</AbstractText><CopyrightInformation>Copyright © 2018 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>DongGwan</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Dept. of Bioindustry and Bioresource Engineering, Dept. of Molecular Biology and Plant Engineering Research Institute, Sejong University, 209, Neungdong-ro, Gwangjin-gu, Seoul, Republic of Korea. Electronic address: kimdg@sejong.ac.kr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bahmani</LastName><ForeName>Ramin</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Dept. of Bioindustry and Bioresource Engineering, Dept. of Molecular Biology and Plant Engineering Research Institute, Sejong University, 209, Neungdong-ro, Gwangjin-gu, Seoul, Republic of Korea. Electronic address: rbahmani@sejong.ac.kr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ko</LastName><ForeName>Jae-Heung</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Plant & Environmental New Resources, Kyung Hee University, Yongin 446-701, Gyeonggi-do, Republic of Korea. Electronic address: jhko@khu.ac.kr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hwang</LastName><ForeName>Seongbin</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Dept. of Bioindustry and Bioresource Engineering, Dept. of Molecular Biology and Plant Engineering Research Institute, Sejong University, 209, Neungdong-ro, Gwangjin-gu, Seoul, Republic of Korea. Electronic address: sbhwang@sejong.ac.kr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>12</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Ecotoxicol Environ Saf</MedlineTA><NlmUniqueID>7805381</NlmUniqueID><ISSNLinking>0147-6513</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000872">Anthocyanins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001559">Benzhydryl Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D052244">Endocrine Disruptors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010636">Phenols</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance></Chemical><Chemical><RegistryNumber>MLT3645I99</RegistryNumber><NameOfSubstance UI="C006780">bisphenol A</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000872" MajorTopicYN="N">Anthocyanins</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017360" MajorTopicYN="N">Arabidopsis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001559" MajorTopicYN="N">Benzhydryl Compounds</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015374" MajorTopicYN="N">Biosensing Techniques</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003124" MajorTopicYN="N">Colorimetry</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D052244" MajorTopicYN="N">Endocrine Disruptors</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018506" MajorTopicYN="N">Gene Expression Regulation, Plant</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010636" MajorTopicYN="N">Phenols</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018515" MajorTopicYN="N">Plant Leaves</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D030821" MajorTopicYN="N">Plants, Genetically Modified</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014157" MajorTopicYN="N">Transcription Factors</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Anthocyanin</Keyword><Keyword MajorTopicYN="N">Arabidopsis thaliana</Keyword><Keyword MajorTopicYN="N">Bisphenol A</Keyword><Keyword MajorTopicYN="N">Endocrine disruptor</Keyword><Keyword MajorTopicYN="N">Estrogen receptor</Keyword><Keyword MajorTopicYN="N">PtrMYB119</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>06</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>12</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>12</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>12</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>2</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>12</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30579163</ArticleId><ArticleId IdType="pii">S0147-6513(18)31320-4</ArticleId><ArticleId IdType="doi">10.1016/j.ecoenv.2018.12.029</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Kim, Donggwan" sort="Kim, Donggwan" uniqKey="Kim D" first="Donggwan" last="Kim">Donggwan Kim</name></region><name sortKey="Bahmani, Ramin" sort="Bahmani, Ramin" uniqKey="Bahmani R" first="Ramin" last="Bahmani">Ramin Bahmani</name><name sortKey="Hwang, Seongbin" sort="Hwang, Seongbin" uniqKey="Hwang S" first="Seongbin" last="Hwang">Seongbin Hwang</name><name sortKey="Ko, Jae Heung" sort="Ko, Jae Heung" uniqKey="Ko J" first="Jae-Heung" last="Ko">Jae-Heung Ko</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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